Author

M. Kanchwala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Organism:human· 3 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Organism:mouse· 2

Frequent Co-Authors

C. Xing· 7 shared H. Dahl· 3 shared N. Delk· 3 shared S. Thomas-Jardin· 3 shared A. Nawas· 2 shared M. Bautista· 2 shared R. Mistry· 2 shared V. Anunobi· 2 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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7 shared papersCancer Biology

C. Xing

Mutual co-authors in cluster

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7 papers

Recent·Most cited

Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis

J. E. Phillips, M. Santos, M. Kanchwala, C. Xing, D. Pan

This study uses genome editing in Capsaspora owczarzaki to show that the Hippo pathway ortholog coYki regulates cytoskeletal dynamics and multicellular shape, suggesting an ancestral role in multicellular morphogenesis.

bioRxiv · Nov 15, 2021Cell Biology

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis

F. Xiao, N. Lam, P. Wang, S. Li, D. Canseco, W. Kimura, X. Luo, N. U. N. Nguyen, W. El Helaly, R. Singh, S. Sadayappan, M. Kanchwala, C. Xing, R. Hajjar, J. Hill, H. Sadek

This study identifies adducin as a regulator of sarcomere disassembly during cardiomyocyte mitosis, showing phosphorylation of a short isoform induces disassembly in neonatal cardiomyocytes.

bioRxiv · Dec 24, 2020Cell Biology

Manipulation of IRE1-dependent MAPK signaling by a Vibrio agonist-antagonist effector pair

N. J. De Nisco, A. K. Casey, M. Kanchwala, A. E. Lafrance, F. S. Coskun, L. N. Kinch, N. V. Grishin, C. Xing, K. Orth

This paper shows how Vibrio parahaemolyticus uses two effectors, VopQ and VopS, to manipulate host signaling by first inducing pro-survival responses and then triggering cell death.

bioRxiv · Sep 1, 2020Microbiology

Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence

H. Dahl, M. Kanchwala, S. Thomas-Jardin, A. Sandhu, P. Kanumuri, A. F. Nawas, C. Xing, C. Lin, D. E. Frigo, N. Delk

This study shows chronic IL-1 exposure leads to androgen and AR independence in LNCaP prostate cancer cells, promoting castration-resistant prostate cancer development.

bioRxiv · Apr 21, 2020Cancer Biology

IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα- BCa and AR- PCa cells and promotes cell survival

A. Nawas, M. Kanchwala, S. Thomas-Jardin, H. Dahl, K. Daescu, M. Bautista, V. Anunobi, A. Wong, R. Meade, R. Mistry, N. Ghatwai, F. Bayerl, C. Xing, N. Delk

The paper identifies a 350-gene set conserved between HR+ and HR- BCa/PCa cells that promotes HR-independent survival and treatment resistance.

bioRxiv · Sep 19, 2019Cancer Biology

RELA is Sufficient to Mediate Interleukin-1 (IL-1) Repression of Androgen Receptor Expression and Activity in LNCaP Disease Progression Model

S. Thomas-Jardin, H. Dahl, M. Kanchwala, F. Ha, J. Jacob, R. Soundharrajan, M. Bautista, A. Nawas, D. Robichaux, R. Mistry, V. Anunobi, C. Xing, N. Delk

This study shows that RELA mediates IL-1 repression of AR mRNA and activity in PCa cells, with stronger effects in castration-resistant sublines.

bioRxiv · Sep 19, 2019Cancer Biology

The IFN response in bat cells consists of canonical and non-canonical ISGs with unique temporal expression kinetics

P. C. De La Cruz-Rivera, M. Kanchwala, H. Liang, A. Kumar, L.-F. Wang, C. Xing, J. Schoggins

This study identifies canonical and non-canonical ISGs in bat cells with distinct temporal expression kinetics, revealing unique aspects of the IFN response that may contribute to viral resistance.

bioRxiv · Jul 24, 2017Immunology