J. Hill

Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice

This study shows that BDNF contributes to activity-induced muscle pain in male mice but not female mice, with no sex differences in BDNF expression changes.

Host JAK/Stat activity is a target of endoparasitoid wasp virulence strategies

This paper shows parasitoid wasps suppress Drosophila JAK-STAT pathway activity to evade immune defenses.

Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

A whole blood intracellular cytokine assay optimised for field site studies demonstrates polyfunctionality of CD4+ T cells in acute scrub typhus

This study optimizes a whole blood intracellular cytokine assay to assess polyfunctional CD4+ T cell responses in acute scrub typhus, demonstrating its utility in field settings with limited resources.

Low mutation load in a supergene underpinning alternative male mating strategies in ruff

The paper examines a supergene in ruffs, finding low mutation load in a recessive lethal allele despite high sequence divergence, suggesting a recent origin and introgression from an extinct lineage.

Spatiotemporal variations in retrovirus-host interactions among Darwin's finches

The paper examines spatiotemporal variations in retrovirus-host interactions among Darwin's finches, revealing shared ERVs pre-dating speciation and population-specific ERV variation linked to historical gene flow and speciation.

Cytologic Scoring of Equine Exercise-Induced Pulmonary Hemorrhage (EIPH): Performance of Human Experts and a Deep Learning-Based Algorithm

This study evaluates the diagnostic accuracy and reproducibility of human experts and a deep learning algorithm for scoring exercise-induced pulmonary hemorrhage in horses using bronchoalveolar lavage fluid.

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis

This study identifies adducin as a regulator of sarcomere disassembly during cardiomyocyte mitosis, showing phosphorylation of a short isoform induces disassembly in neonatal cardiomyocytes.

The eukaryotic replisome requires an additional helicase to disarm dormant replication origins

The paper shows that Pif1 helicase, along with the replisome, removes unfired MCM DHs from replicating DNA, enabling efficient replication and termination.

Global cooling & the rise of modern grasslands: Revealing cause & effect of environmental change on insect diversification dynamics

The paper models speciation rates in Orthoptera to show global cooling correlates with increased speciation and identifies C4 grassland rise as a mechanism linking climate change to insect diversification.

Genomic and proteomic analysis of Human herpesvirus 6 reveals distinct clustering of acute versus inherited forms and reannotation of reference strain

This study sequences HHV-6B and iciHHV-6 genomes, identifies geographic clustering and recombination in active infections, and reannotates the HHV-6B genome using transcriptomics and proteomics.