RNA Sensing and Innate Immunity Constitutes a Barrier for Interspecies Chimerism
Y. Hu, H.-X. Sun, M. Sakurai, A. E. Jones, L. Liu, T. Cheng, C. Zheng, J. Li, B. Ravaux, Z. Luo, Y. Ding, T. Liu, Y. Wu, E. Chen, Z. Chen, , J. Wu
This study identifies RNA sensing and innate immunity in host embryos as a barrier to interspecies chimerism and shows that modifying host embryos can enhance human cell survival in chimeric embryos.
bioRxiv · Mar 7, 2023 · PreprintCell Biology