H.-Y. Lee

Oomycete effector AVRblb2 targets cyclic nucleotide-gated channels through calcium sensors to suppress pattern-triggered immunity

This study identifies AVRblb2 as an effector that targets CNGC channels via CaM/CML proteins to suppress PTI in plants.

The Phytophthora capsici RxLR effector CRISIS2 has roles in suppression of PTI and triggering cell death in host plant

This study identifies CRISIS2, an RxLR effector from Phytophthora capsici, which suppresses plant immunity by interacting with PMA and BAK1, leading to cell death and enhanced pathogen virulence.

Inhibition of Ras1-MAPK pathways for hypha formation by novel drug candidates in Candida albicans

This paper identifies small carbazole derivatives that inhibit C. albicans morphogenesis and pathogenicity by targeting the Ras1/MAPK pathway, showing efficacy in drug-resistant strains and in vivo.

Plant NLR targets P-type ATPase for executing plasma membrane depolarization leading to calcium influx and cell death

The paper shows that the plant NLR CCA309 targets P-type ATPase to cause membrane depolarization, calcium influx, and cell death during hypersensitive response.

CCM 1 determines YAP/TAZ signaling dependent metastatic hallmarks of prostate cancer cells

This study identifies CCM1 as a regulator of YAP/TAZ signaling that promotes prostate cancer metastasis and is inversely correlated with patient survival.

Genome-wide functional analysis of hot pepper immune receptors reveals an autonomous NLR cluster in seed plants

This study identifies an autonomous NLR cluster in seed plants through functional analysis of hot pepper immune receptors, revealing conserved autoactive NLRs that trigger cell death independently of helper NLRs.

Multiple reference genome sequences of hot pepper reveal the massive evolution of plant disease resistance genes by retroduplication

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.