Sustained Humoral Activation through self-amplifying mRNA Vaccination Enhances Longitudinal Antibody Function in a Phase III Trial
Kate S Levine, Ross Blanc, Qixin Wang, Hadar Malca, Rose E. Sekulovich, Hongfan Jin, Sophie N. Liu, Carole Verhoeven, Brian Martin Sullivan, Igor V. Smolenov, Ryan P. McNamara
This study compares antibody responses between two mRNA vaccines, finding that sa-mRNA elicited sustained, activating antibodies with broader coverage against SARS-CoV-2 variants.
The Journal of Immunology · Jul 28, 2026Peer-reviewedImmunology