The paper investigates immune correlates of early Mtb clearance in TB household contacts, finding that BCG vaccination is linked to enhanced innate immune responses rather than adaptive immunity.

Nature Communications · Jan 2, 2025Peer-reviewedImmunology

Epigenetic Reprogramming Mediates Monocyte and Heterologous T Cell-derived Cytokine Responses after BCG Vaccination

Cancan Qi, Zhaoli Liu, Gizem Kılıç, Andrei S. Sarlea, Priya A. Debisarun, Xuan Liu, Yonatan Ayalew Mekonnen, Wenchao Li, Martin Graßhoff, Ahmed Alaswad, Apostolos Petkoglou, Valerie A. C. M. Koeken, Simone J.C.F.M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, , Cheng‐Jian Xu

This study investigates how DNA methylation changes after BCG vaccination influence cytokine responses and identifies epigenetic pathways mediating genetic effects on immune responses.

medRxiv · Mar 27, 2024 · PreprintGenetic & Genomic Medicine

The genetic risk for COVID-19 severity is associated with defective innate immune responses

Yunus Kuijpers, Xiaojing Chu, Martin Jaeger, Simone J.C.F.M. Moorlag, Valerie A. C. M. Koeken, Bowen Zhang, Aline de Nooijer, Inge Grondman, Manoj Kumar Gupta, Nico A. F. Janssen, Vera P. Mourits, L. Charlotte J. de Bree, Quirijn de Mast, Frank L. van de Veerdonk, Leo A. B. Joosten, , Cheng‐Jian Xu

This study explores the physiological significance of genetic variants associated with COVID-19 severity using clinical, immunological, and multi-omics data from large cohorts, identifying pathways for prevention and therapy.

Frontiers in Immunology · May 12, 2022Peer-reviewedGenetic & Genomic Medicine