Reinout van Crevel

This study compares targeted next-generation sequencing (tNGS) and whole-genome sequencing (WGS) for detecting drug resistance and lineage in Mycobacterium tuberculosis samples, finding high concordance for most drugs but some discrepancies in mutation detection and lineage resolution.

This study identifies a new stress-response pathway in Mycobacterium tuberculosis that produces GABA-trehalose under hypoxia and immune stress.

This study shows L2-B Mycobacterium tuberculosis strains evade BCG vaccine-induced immunity by suppressing macrophage activation and trained innate immunity.

The paper improves imputation accuracy for Indonesians by adding West Javanese whole genome sequencing data to existing reference panels.

The paper investigates immune correlates of early Mtb clearance in TB household contacts, finding that BCG vaccination is linked to enhanced innate immune responses rather than adaptive immunity.

This study identifies ancestry-specific eQTLs in TB-T2D patients using cis-eQTL mapping, revealing variants associated with gene expression that could guide therapeutic targets in African populations.

This paper presents an optimized dual RNA-Seq protocol for human macrophages infected with Mycobacterium avium to better study host-pathogen interactions.

The paper uses Bayesian analysis to show the LTA4H TT genotype improves survival in TBM patients in Vietnam and Indonesia, but only when disease severity is not the primary cause of mortality.