Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
Dylan V. Neel, Himanish Basu, Georgia Gunner, Matthew Bergstresser, Richard M. Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza M. Brody, Xin Jiang, Edward B. Lee, Michelle Evelyn Watts, Christine Marques, Aaron Held, Brian J. Wainger, , Isaac M. Chiu
This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.
Neuron · Mar 13, 2023Peer-reviewedNeuroscience