Kevin Ho

Engineered caspases directly rewire mutant Ras to cell death

This paper engineers caspases to selectively kill cells with mutant Ras by reconstituting active complexes upon detection, showing potent in vitro efficacy against cancer lines.

Engineered protein circuits for cancer therapy

This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.

Regulatory T cells crosstalk with tumor and endothelium through lymphotoxin signaling

This study identifies Treg-mediated lymphotoxin signaling that promotes tumor growth and metastasis by activating nonclassical NFκB pathways in tumor and endothelial cells, and shows that targeting this pathway can suppress tumor progression.