Author

Hans J. Friedrichsen

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

Britt HansoniD· 2 shared Matthew J. A. WoodiD· 2 shared Nenad SvrzikapaiD· 2 shared Thomas C. RobertsiD· 2 shared Alicia LjungdahliD· 1 shared Angus J. Lennaárd· 1 shared Dhanu GuptaiD· 1 shared Dongnan Yan· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Britt HansonORCID

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2 papers

Recent·Most cited

Targeted BDNF upregulation via upstream open reading frame disruption

Feng Ning, Thomas Goedert, Nenad Svrzikapa, Dongnan Yan, Hans J. Friedrichsen, Britt Hanson, Alicia Ljungdahl, Ruxandra Dafinca, Kevin Talbot, Stephan Sanders, Dhanu Gupta, Matthew J. A. Wood, Thomas C. Roberts

This study identifies uORF elements regulating BDNF translation and demonstrates that disrupting uORFs can upregulate BDNF expression in cell culture.

Molecular Therapy · Dec 11, 2025Peer-reviewedMolecular Biology

Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach

Britt Hanson, Nenad Svrzikapa, Ning Feng, Hans J. Friedrichsen, Angus J. Lennaárd, Rushdie Abuhamdah, Nicole Hemmer, Katarzyna Chwalenia, Matthew Drake, Yahya E. Jad, Samir EL Andaloussi, Matthew J. A. Wood, Thomas C. Roberts

The paper combines experimental and computational methods to model how uORFs regulate translation, identifying key features and interactions that influence their repressive activity.

bioRxiv · Jul 28, 2025 · PreprintBiochemistry