Interleukin-4 restores neurogenic plasticity of the primary human neural stem cells through suppression of Kynurenic acid production upon Amyloid-β42 toxicity
Christos Papadimitriou, Hilal Çelikkaya, Mehmet İlyas Coşacak, Violeta Mashkaryan, Laura Jane Bray, Prabesh Bhattarai, Kerstin Brandt, Heike Hollak, Xin Chen, Shuijin He, Christopher L. Antos, Weilin Lin, Alvin Kuriakose Thomas, Andreas Dahl, Thomas Kurth, , Çağhan Kızıl
This study shows that IL4 restores neurogenic plasticity of human NSCs by suppressing KAT2, which is upregulated in AD mouse models.
Developmental Cell · Jul 1, 2018Peer-reviewedNeuroscience