Uwe Freudenberg

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

This paper develops scalable fabrication of anisotropic polymeric microfibers for 3D tissue models, showing they guide cell growth in high-throughput systems.

This study shows that heparin promotes endochondral differentiation of MSCs in vitro but chondral development in vivo, with selective anti-hypertrophic effects through SMAD2/3 regulation.

This study shows that mechanical properties and YAP/TAZ activity influence position-dependent cell proliferation during axolotl limb regeneration.

The paper shows that Ngfr promotes neurogenesis and reduces amyloid pathology in AD mouse models by suppressing Lcn2/Slc22a17 signaling.

This study shows that IL4 restores neurogenic plasticity of human NSCs by suppressing KAT2, which is upregulated in AD mouse models.

This paper introduces a 3D hydrogel culture system to model human neural stem cell plasticity, neurogenesis, and neurodegeneration, showing improved neuronal maturation and disease modeling.