Author

Alvin Kuriakose Thomas

Center for Molecular BioengineeringORCID 0000-0002-8544-4983Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Yixin ZhangiD· 3 shared Andreas DahliD· 2 shared Çağhan KızıliD· 2 shared Carsten WerneriD· 2 shared Christopher L. AntosiD· 2 shared Christos PapadimitriouiD· 2 shared Heike Hollak· 2 shared Hilal ÇelikkayaiD· 2 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Yixin ZhangORCID

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3 papers

Recent·Most cited

Interleukin-4 restores neurogenic plasticity of the primary human neural stem cells through suppression of Kynurenic acid production upon Amyloid-β42 toxicity

Christos Papadimitriou, Hilal Çelikkaya, Mehmet İlyas Coşacak, Violeta Mashkaryan, Laura Jane Bray, Prabesh Bhattarai, Kerstin Brandt, Heike Hollak, Xin Chen, Shuijin He, Christopher L. Antos, Weilin Lin, Alvin Kuriakose Thomas, Andreas Dahl, Thomas Kurth, , Çağhan Kızıl

This study shows that IL4 restores neurogenic plasticity of human NSCs by suppressing KAT2, which is upregulated in AD mouse models.

Developmental Cell · Jul 1, 2018Peer-reviewedNeuroscience

Modelling Large, Dynamic, and Heterogeneous Populations Using DNA Libraries

Helena Andrade, Alvin Kuriakose Thomas, Weilin Lin, Francesco V. Reddavide, Yixin Zhang

The paper introduces an RT-PCR-based method to model large, dynamic, and heterogeneous populations using DNA libraries, demonstrating applications in drug discovery and population dynamics.

bioRxiv · Mar 5, 2018 · PreprintBioinformatics

Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegeneration

Christos Papadimitriou, Mehmet İlyas Coşacak, Violeta Mashkaryan, Hilal Çelikkaya, Laura Jane Bray, Prabesh Bhattarai, Heike Hollak, Xin Chen, Shuijin He, Christopher L. Antos, Alvin Kuriakose Thomas, Jens Friedrichs, Andreas Dahl, Yixin Zhang, Uwe Freudenberg, , Çağhan Kızıl

This paper introduces a 3D hydrogel culture system to model human neural stem cell plasticity, neurogenesis, and neurodegeneration, showing improved neuronal maturation and disease modeling.

bioRxiv · Nov 27, 2017 · PreprintNeuroscience