Author

Howard H. Yang

National Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aydın BuluçiD· 1 shared Can Kızılkale· 1 shared Charli Gruen· 1 shared Chi-Ping DayiD· 1 shared Christina Marcelus· 1 shared Erfan Sadeqi AzeriD· 1 shared Eva Pérez‐GuijarroiD· 1 shared Farid Rashidi MehrabadiiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Aydın BuluçORCID

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2 papers

Recent·Most cited

Metabolic-epigenetic coupling between leucine catabolism and glycolysis drives CDK4/6 inhibitor resistance

Michael UJ Oliphant, Klarisa Norton, Kiran Kurmi, Howard H. Yang, Shakchhi Joshi, Jonah Lee, Nina Kozlova, Taru E. Muranen, John G. Clohessy, Marcia C. Haigis, Senthil K. Muthuswamy

This study identifies a metabolic-epigenetic mechanism linking leucine catabolism to glycolysis that drives resistance to CDK4/6 inhibitors in ER+ breast cancer.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology

Profiles of expressed mutations in single cells reveal subclonal expansion patterns and therapeutic impact of intratumor heterogeneity

Farid Rashidi Mehrabadi, Kerrie L. Marie, Eva Pérez‐Guijarro, Salem Malikić, Erfan Sadeqi Azer, Howard H. Yang, Can Kızılkale, Charli Gruen, Welles Robinson, Huaitian Liu, Michael C. Kelly, Christina Marcelus, Sandra Sczerba Burkett, Aydın Buluç, Funda Ergün, , S. Cenk Şahinalp

Trisicell infers subclonal expansion patterns and therapeutic impact of intratumor heterogeneity from scRNAseq data, revealing correlations between mutational composition and tumor aggressiveness.

bioRxiv · Mar 26, 2021 · PreprintBioinformatics