Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling
Sergei Kutseikin, Maria Rafiq, Prerona Bora, Shanshan Liu, Rick A. Homan, Jeffrey T. Mindrebo, Matthew Holcomb, H. Michael Petrassi, Huang Qiu, Anastasiya Redkina, Justyna Sosna, Thanh-Trang Lee, Xiao Hu, Stefano Forli, Christopher G. Parker, , Luke Wiseman
This study shows that IXA4 inhibits SLC33A1, causing ER hyperoxidation and activating IRE1/XBP1s signaling, which reduces viability of KEAP1-deficient lung cancer cells.
bioRxiv · Feb 18, 2026 · PreprintCell Biology