Shanshan Liu

Eleven deep-sea coral genome assemblies unveil insights into evolution, adaptation, and coral biodiversity

The paper presents 11 deep-sea coral genome assemblies, revealing evolutionary dynamics, environmental adaptation, and genetic differences between deep-sea and shallow-sea corals.

ExMODE: A Multi-Omics Repository for Extremophile Adaptation and Bioprospecting

ExMODE is a multi-omics database for extremophiles that integrates and standardizes data to enable comparative analysis and bioprospecting.

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

This study identifies SLC33A1 as the major ER GSSG exporter, showing its role in maintaining ER redox balance and protein maturation through direct GSSG transport and regulation of PDIs.

Genetic dissection of rapid proteolysis identifies TXNDC15 as a key factor of ERAD and lipid homeostasis

The paper identifies TXNDC15 as a key factor in ERAD and lipid homeostasis through CRISPR-based screens and proteolysis analysis.

Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling

This study shows that IXA4 inhibits SLC33A1, causing ER hyperoxidation and activating IRE1/XBP1s signaling, which reduces viability of KEAP1-deficient lung cancer cells.

4D Single-Cell Spatial Transcriptomics Reveals Dynamic Morphogenetic Gradients and Regenerative Domains in Planarians

This study constructs a 4D spatiotemporal transcriptomic map of planarian regeneration using Stereo-seq, identifying dynamic gradients and an injury-induced regenerative zone.