Kıvanç Birsoy

Macronutrient Composition and Genetic Background Determine the Response to a Ketogenic Diet

This study shows that macronutrient composition and genetic background influence the response to a ketogenic diet in mice, with B6J mice losing weight on a low-protein KD due to increased GDF15 and LCN2 levels.

Diverse high-fat diets drive multi-omic reprogramming that persists after dietary reversal

The paper investigates how different high-fat diets affect host and microbiome multi-omic states over time and shows that some changes persist even after returning to a control diet.

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

This study identifies SLC33A1 as the major ER GSSG exporter, showing its role in maintaining ER redox balance and protein maturation through direct GSSG transport and regulation of PDIs.

Genetic dissection of rapid proteolysis identifies TXNDC15 as a key factor of ERAD and lipid homeostasis

The paper identifies TXNDC15 as a key factor in ERAD and lipid homeostasis through CRISPR-based screens and proteolysis analysis.

Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling

This study shows that IXA4 inhibits SLC33A1, causing ER hyperoxidation and activating IRE1/XBP1s signaling, which reduces viability of KEAP1-deficient lung cancer cells.

Tumor Genotype Dictates Mitochondrial and Immune Vulnerabilities in Liver Cancer

This study identifies genotype-specific mitochondrial metabolic vulnerabilities in liver cancer and shows that phosphatidylethanolamine synthesis contributes to immune evasion.

Glycosaminoglycan-mediated lipoprotein uptake protects cancer cells from ferroptosis

This study identifies glycosaminoglycan-mediated lipoprotein uptake as a mechanism by which cancer cells resist ferroptosis and lipid oxidative stress.

GeneMAP: A discovery platform for metabolic gene function

GeneMAP uses GWAS and multiomic data to predict gene-metabolite associations, identifying SLC25A48 as a mitochondrial choline transporter.

A mouse model to study glutathione limitation in vivo

This study develops a conditional mouse model to investigate the role of glutathione availability in physiology and disease by expressing a bacterial glutathione-synthesizing enzyme.

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.

The paper identifies ATRAID as a gene critical for the response to nitrogen-containing bisphosphonates, showing its role in drug efficacy and resistance in osteoporosis.

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo

The paper introduces MITO-Tag Mice to isolate mitochondria from specific cell types in vivo and identifies mitochondrial metabolite changes during fasting and refeeding in hepatocytes.