Author

D. S. Zamboni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:human· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. Arruda· 3 shared A. Fabro· 2 shared F. P. Veras· 2 shared H. I. Nakaya· 2 shared I. A. Castro· 2 shared J. C. Alves-Filho· 2 shared M. C. Pontelli· 2 shared P. Louzada-Junior· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersPharmacology & Toxicology

E. Arruda

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The unique Legionella longbeachae capsule favors intracellular replication and immune evasion

S. Schmidt, S. Mondino, L. Gomez-Valero, P. Escoll, D. P. Mascarenhas, A. Goncalves, C. Rusniok, M. Sachse, M. Moya-Nilges, T. Fontaine, D. S. Zamboni, C. Buchrieser

This study identifies a unique capsule in Legionella longbeachae that enhances intracellular replication and immune evasion, distinguishing it from other Legionella species.

bioRxiv · Nov 22, 2023 · PreprintMicrobiology

In Vitro Inhibition of SARS-CoV-2 Infection by Bromhexine hydrochloride

R. Martins, I. Ferreira, D. M. Jorge, L. Almeida, J. d. P. Souza, M. C. Pontelli, I. A. Castro, T. Melquiades, R. M. Mendes Viana, D. S. Zamboni, P. Marcato, E. Arruda

This study shows bromhexine hydrochloride inhibits SARS-CoV-2 infection in vitro by targeting TMPRSS2, reducing viral entry and progeny without direct virucidal activity.

bioRxiv · Dec 23, 2022 · PreprintPharmacology & Toxicology

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

B. M. Silva, F. P. Veras, G. Gomes, S. Cambier, G. Silva, A. Quadros, D. Caetite, D. Nascimento, C. Silva, J. Silva, S. Damasceno, A. Schneider, F. Beretta, S. Batah, I. Castro, , T. M. Cunha

This study shows that inhibiting C5aR1 signaling reduces neutrophil extracellular traps and improves lung pathology in COVID-19.

bioRxiv · Jul 3, 2022Immunology

Infection of human lymphomononuclear cells by SARS-CoV-2

M. C. Pontelli, I. A. Castro, R. B. Martins, F. P. Veras, L. La Serra, D. C. Nascimento, R. S. Cardoso, R. Rosales, T. M. Lima, J. P. Souza, D. B. Caetite, M. H. Lima, J. T. Kawahisa, M. C. Giannini, L. P. Bonjorno, , E. Arruda

This study investigates SARS-CoV-2 infection of human lymphomononuclear cells in vitro and in vivo, finding that monocytes, B cells, and T cells are susceptible to infection and viral replication.

bioRxiv · Jul 28, 2020Microbiology

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

D. X. Ji, K. C. Witt, D. I. Kotov, S. R. Margolis, A. Louie, V. Chevee, K. J. Chen, M. Gaidt, H. S. Dhaliwal, A. Y. Lee, S. Nishimura, D. S. Zamboni, I. Kramnik, D. A. Portnoy, K. H. Darwin, R. E. Vance

This study identifies SP140 as a repressor of type I interferons that enhances resistance to bacterial infections like Legionella pneumophila and Mycobacterium tuberculosis.

bioRxiv · Jan 7, 2020Immunology

Systems Analysis of Subjects Acutely Infected with Chikungunya Virus

A. Soares-Schanoski, N. Baptista-Cruz, L. A. Castro-Jorge, R. V. Carvalho, C. A. Santos, N. Ros, U. Oliveira, D. D. Costa, C. L. Santos, M. P. Cunha, M. L. Oliveira, J. C. Alves, R. A. Ocea, D. R. Ribeiro, A. N. Goncalves, , H. I. Nakaya

This study uses systems biology to analyze blood transcriptomes of CHIKV-infected adults, identifying gene signatures linked to viral RNA and symptoms, and comparing them to dengue and rheumatoid arthritis.

bioRxiv · Jan 28, 2019Immunology