Age-associated failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging
M. G. Perino, M. Calvo-Rubio Barrera, D. Riordon, G. Agnetti, K. Tarasov, A. Parveen, K. Chakir, C. Morrell, I. Ahmet, A. Lyashkov, Y. Lukyanenko, Y. Tarasova, J. Qu, H. Kadioglu, M. Ranek, , E. Lakatta
This study shows that aging impairs proteostatic mechanisms in mice with cardiac-specific over-expression of adenylyl cyclase VIII, leading to accelerated heart aging and cardiomyopathy.
bioRxiv · Aug 13, 2023 · PreprintCell Biology