Author

R. deCabo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:metabolism & bioenergetics· 3 Assay:metabolomics· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2

Frequent Co-Authors

I. Ahmet· 3 shared C. H. Morrell· 2 shared E. G. Lakatta· 2 shared K. Chakir· 2 shared M. G. Perino· 2 shared M. Ranek· 2 shared A. Ahmed· 1 shared A. E. Kane· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

I. Ahmet

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

A. E. Kane, K. Chellappa, M. B. Schultz, M. Arnold, J. Li, J. Amorim, C. Diener, D. Zhu, S. J. Mitchell, P. T. Griffin, X. Tian, C. Petty, R. Conway, K. Walsh, L. Shelerud, , D. A. Sinclair

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

bioRxiv · Jun 21, 2024 · PreprintPharmacology & Toxicology

Age-associated failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging

M. G. Perino, M. Calvo-Rubio Barrera, D. Riordon, G. Agnetti, K. Tarasov, A. Parveen, K. Chakir, C. Morrell, I. Ahmet, A. Lyashkov, Y. Lukyanenko, Y. Tarasova, J. Qu, H. Kadioglu, M. Ranek, , E. Lakatta

This study shows that aging impairs proteostatic mechanisms in mice with cardiac-specific over-expression of adenylyl cyclase VIII, leading to accelerated heart aging and cardiomyopathy.

bioRxiv · Aug 13, 2023 · PreprintCell Biology

A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8

K. V. Tarasov, K. Chakir, D. R. Riordon, A. E. Lyashkov, I. Ahmet, M. G. Perino, A. J. Silvester, J. Zhang, M. Wang, Y. O. Lukyanenko, J.-H. Qu, M. C.-R. Barrera, M. Juhaszova, Y. S. Tarasova, B. Ziman, , E. G. Lakatta

This study shows that cardiac-specific overexpression of AC8 in mice leads to adaptive cardiac changes resembling cancer-like survival mechanisms without heart failure.

bioRxiv · May 20, 2022Physiology

Emergence of Heartbeat Frailty in Advanced Age: Perspectives from Life-Long EKG Recordings in Mice

J. M. Moen, C. H. Morrell, I. Ahmet, M. G. Matt, M. Davoodi, M. Petr, S. Charles, R. deCabo, Y. Yaniv, E. G. Lakatta

This study tracks EKG recordings in mice to identify age-related changes in heart rhythm variability, linking them to signs of cardiac and systemic frailty in advanced age.

bioRxiv · Jan 12, 2022 · PreprintPhysiology

Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness

A. P. Gomes, D. Ilter, V. Low, J. Endress, J. Fernandez-Garcia, A. Rosenzweig, T. Schild, D. Broekaert, A. Ahmed, M. Planque, I. Elia, J. Han, C. Kinzig, E. Mullarky, A. Mutvei, , J. Blenis

The paper shows that methylmalonic acid accumulation with age promotes tumor progression by inducing SOX4 and reprogramming cancer cells.

bioRxiv · Jun 4, 2020 · PreprintCancer Biology