R. J. Xavier

Early cellular and molecular signatures correlate with severity of West Nile Virus infection

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

Lectin-Seq: a method to profile lectin-microbe interactions in native communities

Lectin-Seq profiles lectin-microbe interactions in human fecal microbiota, revealing distinct binding preferences for MBL and hItln1.

Multi-omic analysis along the gut-brain axis points to a functional architecture of autism

The paper identifies a functional architecture of autism along the gut-brain axis using multi-omic data, revealing microbial and metabolic profiles linked to autism symptoms.

Remodeling of human colon plasma cell repertoire in ulcerative colitis

This study characterizes the remodeling of the human colon plasma cell repertoire in ulcerative colitis, showing clonal expansion, isotype skewing, and altered gene expression associated with inflammation.

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

The paper identifies DCA as a CDK8 inhibitor that induces a tolerogenic immunophenotype in CD4+ T cells through a novel CDK8-GATA3-FOXP3 pathway, promoting Treg and Th2 differentiation while inhibiting Th1 and Th17.

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

The paper shows that YKL-05-099, which inhibits SIKs and CSF1R, increases bone formation without increasing bone resorption in mice.

Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling

This study shows IL-23R signaling enables Th1 cells to acquire a colitogenic phenotype, distinct from Th17 cells, and identifies CD160 as a key regulator.

Human gut bacteria produce TH17-modulating bile acid metabolites

This study identifies human gut bacteria that produce TH17-modulating bile acid metabolites, showing reduced levels in IBD patients.

Delivery mode impacts newborn gut colonization efficiency

This study investigates how delivery mode affects newborn gut microbiome colonization, finding that C-section infants lack Bacteroides species, but these are not due to birth canal exposure.

Industrialization is associated with elevated rates of horizontal gene transfer in the human microbiome

The paper shows that horizontal gene transfer in the human microbiome is more common within the same host and is linked to industrialization and lifestyle factors.

Adaptive evolution within the gut microbiome of individual people

This study tracks genetic adaptation of B. fragilis in individual human gut microbiomes over time, revealing persistent evolutionary dynamics and niche differentiation within a single host.