Author

K. J. Flynn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Arnett· 2 shared B. Khor· 2 shared K. G. Moo· 2 shared P. D. Schloss· 2 shared A. E. Wiedeman· 1 shared A. F. Shamji· 1 shared A. M. Schubert· 1 shared C. J. Greenbaum· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

A. Arnett

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The gut bacterial community potentiates Clostridioides difficile infection severity

N. A. Lesniak, A. M. Schubert, K. J. Flynn, J. L. Leslie, H. Sinani, I. L. Bergin, V. B. Young, P. D. Schloss

This study shows that gut bacterial communities influence the severity of Clostridioides difficile infections in mice, with certain bacterial groups linked to more or less severe outcomes.

bioRxiv · Jan 31, 2022Microbiology

Permutational immune analysis reveals architectural similarities between inflammaging, Down syndrome and autoimmunity

K. Lambert, K. G. Moo, A. Arnett, G. Goel, K. J. Flynn, C. Speake, A. E. Wiedeman, C. J. Greenbaum, S. A. Long, R. Partridge, J. H. Buckner, B. Khor

The paper uses permutational analysis to reveal advanced immune aging in Down syndrome and type 1 diabetes.

bioRxiv · Sep 13, 2021 · PreprintImmunology

The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway

A. Arnett, K. G. Moo, K. J. Flynn, T. B. Sundberg, L. Johannessen, A. F. Shamji, N. S. Gray, T. Decker, V. H. Gersuk, D. E. Levy, I. J. Marie, Z. S. Rahman, Y. Zheng, P. S. Linsley, R. J. Xavier, B. Khor

The paper identifies DCA as a CDK8 inhibitor that induces a tolerogenic immunophenotype in CD4+ T cells through a novel CDK8-GATA3-FOXP3 pathway, promoting Treg and Th2 differentiation while inhibiting Th1 and Th17.

bioRxiv · Mar 4, 2021 · PreprintImmunology

Spatial variation of the native colon microbiota in healthy adults

K. J. Flynn, M. T. Ruffin, D. K. Turgeon, P. D. Schloss

The paper profiles the microbiota of the healthy colon to identify spatial variations between proximal and distal regions using 16S rRNA gene sequencing and classification models.

bioRxiv · Feb 14, 2018Microbiology