Author

I. Kucharska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

J.-P. Julien· 4 shared J. L. Rubinstein· 2 shared A. Amen· 1 shared A. Fabra-Garcia· 1 shared A. Jetha· 1 shared A. Srivastava· 1 shared A. Sultana· 1 shared B. Correia· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersImmunology

J.-P. Julien

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats

A. Amen, R. Yoo, A. Fabra-Garcia, J. Bolscher, W. J. R. Stone, I. Bally, S. Dergan-Dylon, I. Kucharska, R. M. de Jong, M. de Bruijni, T. Bousema, C. R. King, R. S. MacGill, R. W. Sauerwein, J.-P. Julien, , M. M. Jore

The paper identifies human antibodies targeting Plasmodium falciparum sexual stages, revealing cross-stage recognition of glutamate-rich repeats through a novel method.

bioRxiv · Nov 3, 2023 · PreprintImmunology

Antibody avidity and multi-specificity combined to confer protection against SARS-CoV-2 and resilience against viral escape

C. Burn Aschner, K. Muthuraman, I. Kucharska, H. Cui, K. Prieto, M. S. Nair, M. Wang, Y. Huang, N. Christie-Holmes, B. Poon, J. Lam, A. Sultana, R. Kozak, S. Mubareka, J. L. Rubinstein, , J.-P. Julien

This study develops a multimeric antibody platform (Multabody) that enhances neutralization potency and breadth against SARS-CoV-2 and its variants through avidity and multi-specificity.

bioRxiv · Oct 23, 2022 · PreprintImmunology

A molecular switch modulates assembly and host factor binding of the HIV-1 capsid

R. T. Schirra, N. F. dos Santos, K. K. Zadrozny, I. Kucharska, B. K. Ganser-Pornillos, O. Pornillos

This study identifies a molecular switch in HIV-1 capsid protein that controls capsid assembly and host factor binding, and is a target for the inhibitor lenacapavir.

bioRxiv · Aug 25, 2022Microbiology

Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11

I. Kucharska, E. Thai, A. Srivastava, J. L. Rubinstein, R. Pomes, J.-P. Julien

This study investigates how antibody 3D11 binds to Plasmodium berghei CSP repeats, inducing structural ordering and revealing common mechanisms of antibody evolution against Plasmodium CSP.

bioRxiv · Jun 2, 2020Microbiology

De novo protein design enables precise induction of functional antibodies in vivo

F. Sesterhenn, C. Yang, J. Cramer, J. Bonet, X. Wen, L. Abriata, I. Kucharska, C.-I. Chiang, Y. Wang, G. Castoro, S. Vollers, M. Galloux, R. Charles-Adrien, E. Dheilly, S. Rosset, , B. Correia

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.

bioRxiv · Feb 14, 2020 · PreprintBioengineering