Author

T. D. Bold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

J. M. Thiede· 3 shared R. A. Langlois· 3 shared V. D. Menachery· 3 shared W. E. Matchett· 3 shared M. K. Jenkins· 2 shared A. E. Kennedy· 1 shared A. G. Soerens· 1 shared A. R. Gress· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

J. M. Thiede

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

SARS-CoV-2 infection is associated with intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized COVID-19 patients

C. M. Basting, R. Langat, C. A. Broedlow, C. Guerrero, T. D. Bold, M. Bailey, A. Velez, T. Schroeder, J. Short-Miller, R. Cromarty, Z. Mayer, P. J. Southern, T. W. Schacker, S. E. Safo, C. T. Bramante, , N. R. Klatt

This study examines the impact of SARS-CoV-2 infection on intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized patients, finding associations between specific microbial changes and disease severity.

bioRxiv · Dec 7, 2023 · PreprintMicrobiology

Trem2 Promotes Foamy Macrophage Lipid Uptake and Survival in Atherosclerosis

M. T. Patterson, M. M. Firulyova, Y. Xu, C. Bishop, A. Zhu, P. R. Schrank, C. E. Ronayne, G. Fredrickson, A. E. Kennedy, N. Acharya, X. Revelo, I. M. Stromnes, T. D. Bold, K. Zaitsev, J. W. Williams

This study identifies Trem2 as a regulator of foamy macrophage differentiation and atherosclerotic plaque growth, showing its role in lipid uptake and cell survival.

bioRxiv · Nov 28, 2022Immunology

Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity

W. E. Matchett, V. Joag, J. M. Stolley, F. K. Shephard, C. F. Quarnstrom, C. K. Mickelson, S. Wijeyesinghe, A. G. Soerens, S. Becker, J. M. Thiede, E. Weyu, S. O'Flanagan, J. Walter, M. N. Vu, V. D. Menachery, , D. Masopust

This study shows that a nucleocapsid protein vaccine provides protective immunity against SARS-CoV-2, independent of spike protein targeting, in animal models.

bioRxiv · Apr 26, 2021Immunology

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

J. K. Fiege, J. M. Thiede, H. Nanda, W. E. Matchett, P. J. Moore, N. R. Montanari, B. K. Thielen, J. Daniel, E. Stanley, R. C. Hunter, V. D. Menachery, S. S. Shen, T. D. Bold, R. A. Langlois

This study investigates SARS-CoV-2 tropism, antiviral responses, and therapy effectiveness in human airway epithelium using single-cell RNA-sequencing and flow cytometry.

bioRxiv · Oct 19, 2020Microbiology

SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease

T. J. Gniadek, J. M. Thiede, W. E. Matchett, A. R. Gress, K. A. Pape, M. K. Jenkins, V. D. Menachery, R. A. Langlois, T. D. Bold

The paper assesses SARS-CoV-2 neutralization and serology in convalescent plasma from non-severe COVID-19 donors, finding correlations between binding activity and neutralization.

bioRxiv · Aug 7, 2020Immunology