Author

I. Peran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. A. Lekan· 1 shared A. Bremer· 1 shared A. Deshpande· 1 shared A. Duttargi· 1 shared A. K. Gonsiewski· 1 shared A. Nasir· 1 shared B. T. Harris· 1 shared E. Chen· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. A. Lekan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer

Z. X. Malchiodi, A. A. Lekan, R. K. Suter, A. Deshpande, I. Peran, B. T. Harris, A. Duttargi, M.-J. Chien, S. Hariharan, L. Wetherill, S. Arslan, S. A. Jablonski, W. J. Ho, M. Afifi, E. J. Fertig, L. M. Weiner

The paper identifies periductal fibroblast density as a key factor in immune exclusion in pancreatic cancer, showing that CD44-dependent stromal checkpoints restrict leukocyte access to tumor epithelium.

bioRxiv · May 23, 2024Cancer Biology

Deciphering how naturally occurring sequence features impact the phase behaviors of disordered prion-like domains

A. Bremer, M. Farag, W. M. Borcherds, I. Peran, E. W. Martin, R. V. Pappu, T. Mittag

The paper identifies how specific amino acid compositions influence phase separation in prion-like domains and develops a model to simulate these behaviors.

bioRxiv · Jan 1, 2021Biophysics

Environmentally Induced Sperm RNAs Transmit Cancer Susceptibility to Offspring in a Mouse Model

R. S. da Cruz, O. Dominguez, E. Chen, A. K. Gonsiewski, A. Nasir, M. I. Cruz, X. Zou, S. Galli, K. Makambi, M. McCoy, M. O. Schmidt, L. Jin, I. Peran, S. de Assis

This study shows that DDT exposure in male mice alters sperm RNAs, which transmit cancer susceptibility to female offspring through miRNA-10b, leading to increased tumor aggressiveness.

bioRxiv · Mar 23, 2020 · PreprintCancer Biology