Author

I. Tews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:bacteria (other)· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. M. Orville· 2 shared A. S. L. Sudol· 2 shared J. S. Webb· 2 shared J. Stubbs· 2 shared M. Crispin· 2 shared M. Maly· 2 shared R. Bolton· 2 shared A. Hutchin· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

A. M. Orville

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Droplet microfluidics for time-resolved serial crystallography

J. Stubbs, T. Hornsey, N. Hanrahan, L. Blay-Esteban, R. Bolton, M. Maly, S. Basu, J. Orlans, D. de Sanctis, J.-u. Shim, P. D. Shaw Stewart, A. M. Orville, I. Tews, J. West

This paper develops a droplet microfluidics approach to produce uniform crystals and enable rapid micromixing for time-resolved serial crystallography.

bioRxiv · Jan 12, 2024Biochemistry

Bespoke conformation and antibody recognition distinguishes the streptococcal immune evasion factors EndoS and EndoS2

A. S. L. Sudol, I. Tews, M. Crispin

This study compares the structural differences between EndoS and EndoS2 to explain their distinct IgG recognition and immune evasion mechanisms.

bioRxiv · Aug 15, 2023 · PreprintImmunology

A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron binding protein FutA from Prochlorococcus

R. Bolton, M. M. Machelett, J. Stubbs, D. Axford, N. Caramello, L. Catapano, M. Maly, M. J. Rodrigues, C. Cordery, G. J. Tizzard, F. MacMillan, S. Engilberge, D. von Stetten, T. Tosha, H. Sugimoto, , I. Tews

This paper reveals a redox switch in the cyanobacterial iron binding protein FutA that allows it to bind both Fe(II) and Fe(III) ions through structural analysis.

bioRxiv · May 23, 2023 · PreprintBiophysics

Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS

A. S. L. Sudol, J. Butler, D. P. Ivory, I. Tews, M. Crispin

This study presents crystal structures of IdeS and EndoS in complex with IgG1 Fc, revealing their distinct mechanisms of antibody recognition and cleavage.

bioRxiv · Jun 19, 2022Immunology

LILRB3 (ILT5) is a myeloid checkpoint on myeloid cells that elicits profound immununomodulation

M. Yeboah, C. Papagregoriou, D. C. Jones, H. T. C. Chan, G. Hu, J. S. McPartlan, T. Schiott, U. Mattson, C. I. Mockridge, U.-C. Tornberg, B. Hambe, A. Ljungars, M. Mattsson, I. Tews, M. J. Glennie, , A. Roghanian

This study identifies LILRB3 as a myeloid checkpoint receptor that suppresses immune responses through agonistic monoclonal antibodies, showing immunosuppressive effects in vitro and in humanized mice.

bioRxiv · Jun 4, 2020Immunology

Differential impact on motility and biofilm dispersal of closely related phosphodiesterases in Pseudomonas aeruginosa

Y.-M. Cai, A. Hutchin, J. Craddock, M. A. Walsh, J. S. Webb, I. Tews

This study examines how closely related phosphodiesterases in Pseudomonas aeruginosa affect motility and biofilm dispersal through c-di-GMP regulation.

Scientific Reports · Apr 10, 2020Peer-reviewedMicrobiology