Author

Federico Iseppon

University College LondonORCID 0000-0002-1981-1204Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

John N. WoodiD· 3 shared Ana Paula LuiziD· 2 shared James J. CoxiD· 2 shared Manuel Arcangeletti· 2 shared Rayan HarouniD· 2 shared Samuel J. GossageiD· 2 shared Alexander D. Fudge· 1 shared Ali Lam· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

John N. WoodORCID

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Author profile →

4 papers

Recent·Most cited

E-Selectin Orchestrates IL-1B-Dependent Neuroinflammation via NLRP3 in Vincristine-Induced Neuropathy

Hana Starobova, Ammar Alshammari, Nikhil Nageshwar Inturi, Nicolette Tay, Svetlana Shatunova, Ali Lam, Quan Hoang Nguyen, Marisol Mancilla Moreno, Diana Tavares‐Ferreira, Federico Iseppon, Rodríguez Menéndez, C Meregalli, Brittany Hill, Larissa Labzin, Simranpreet Kaur, , Irina Vetter

This study identifies E-selectin as a key driver of IL-1B-dependent neuroinflammation in vincristine-induced neuropathy and suggests targeting E-selectin as a therapeutic strategy.

bioRxiv · Sep 29, 2026 · PreprintNeuroscience

Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes

Muhammad Ali Bangash, Cankut Çubuk, Federico Iseppon, Rayan Haroun, Chloe Garcia, Ana Paula Luiz, Manuel Arcangeletti, Samuel J. Gossage, Sonia Santana‐Varela, James J. Cox, Myles Lewis, John N. Wood, Jing Zhao

The paper identifies analgesic targets in mouse sensory neurons by analyzing translatomes in somata and terminals under different pain conditions.

Cell Reports · Aug 1, 2024Peer-reviewedNeuroscience

Novel therapies for cancer-induced bone pain

Rayan Haroun, Samuel J. Gossage, Federico Iseppon, Alexander D. Fudge, Sara Caxaria, Manuel Arcangeletti, Charlotte Leese, Bazbek A. Davletov, James J. Cox, Shafaq Sikandar, Fraser Welsh, Iain P. Chessell, John N. Wood

This study evaluates three potential treatments for cancer-induced bone pain in mice, finding that dual inhibition of NGF and TNF significantly reduces pain-related behaviors.

Neurobiology of Pain · Jul 1, 2024Peer-reviewedNeuroscience

Pregabalin silences oxaliplatin-activated sensory neurons to relieve cold allodynia

Federico Iseppon, Ana Paula Luiz, John E. Linley, John N. Wood

This study shows pregabalin reduces cold allodynia caused by oxaliplatin by silencing specific sensory neurons through the 2{delta}-1 subunit of voltage-gated calcium channels.

eNeuro · Jan 31, 2023Peer-reviewedNeuroscience