Microglial Fructose Metabolism Is Essential for Glioblastoma Growth
Leah K. Billingham, Susan L DeLay, Yasmina Eshac, Tzu-Yi Chia, Shashwat Tripathi, Ian E Olson, Kaylee Zilinger, Jay Subbiah, Zhaoquan Wang, Nishanth S. Sadagopan, Hinda Najem, Guillaume Cognet, Joshua L. Katz, Ruochen Du, Khizar Rehan Nandoliya, , Jason M. Miska
This study shows that microglial fructose metabolism via GLUT5 is critical for glioblastoma growth, as GLUT5-KO mice live longer with reduced tumor progression.
Proceedings of the National Academy of Sciences · Mar 17, 2026Peer-reviewedCancer Biology