This study identifies NKX6-2 as a driver of gastric differentiation in IPMNs, linking its expression to indolent biological potential and progression.

Cancer Discovery · Jun 7, 2023Peer-reviewedCancer Biology

Cardiovascular Hemodynamics in Mice with Tumor Necrosis Factor Receptor - Associated Factor 2 Mediated Cytoprotection in the Heart

A. G. Marshall, K. Neikirk, Z. Vue, H. K. Beasley, E. Garza-Lopez, L. Vang, T. Barongan, Z. Evans, A. Crabtree, E. Spencer, J. Anudokem, R. Parker, J. Davis, D. Stephens, S. Damo, , A. K. Reddy

This study evaluates global cardiac function in mice with cardiac-restricted TRAF2 overexpression, finding diminished cardiac function despite reported tolerance to ischemic insults.

bioRxiv · Sep 3, 2022Biophysics

A versatile, high-efficiency platform for CRISPR-based gene activation

A. J. Heidersbach, K. M. Dorighi, J. A. Gomez, A. M. Jacobi, B. Haley

This paper introduces a high-efficiency CRISPRa platform combining piggyBac transposon technology and optimized guide RNA scaffolds to enable rapid, stable gene activation in diverse cellular contexts.

bioRxiv · Jul 21, 2022Bioengineering

Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging

Z. Vue, K. Neikirk, L. Vang, E. Garza-Lopez, T. A. Christensen, J.-q. Shao, J. Lam, H. K. Beasley, A. G. Marshall, A. Crabtree, J. Anudokem, B. Rodriguez, B. Kirk, S. Bacevac, T. Barongan, , A. Hinton

This study uses 3D imaging to show that mitochondria in aging mouse hearts lose cristae structure and volume, similar to mutations in MICOS complex genes.

bioRxiv · Apr 23, 2022Biophysics

Sox6: A new modulator of renin expression during physiological conditions

M. Saleem, C. P. Hodgkinson, E. W. Contreras, L. Xiao, J. A. Gimenez-Bastida, J. Foss, A. J. Payne, M. Mirotsou, V. Gama, V. J. Dzau, J. A. Gomez

This study identifies Sox6 as a regulator of renin expression in juxtaglomerular cells during physiological and pathophysiological conditions.

bioRxiv · Feb 25, 2019 · PreprintPhysiology