Author

P.-Y. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C.-Y. Tsai· 2 shared J.-T. Jan· 2 shared Y.-C. Chou· 2 shared Y.-P. Hsueh· 2 shared A. Tsirigos· 1 shared B. Jiang· 1 shared C. Ma· 1 shared C.-H. Wong· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

C.-Y. Tsai

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Genetic basis and evolution of structural color polymorphism in an Australian songbird

S. Y. W. Sin, F. Ke, G. Chen, P.-Y. Huang, E. Enbody, J. Karubian, M. Webster, S. V. Edwards

The paper investigates the genetic basis of melanism in white-winged fairywren subspecies, finding that the mainland blue subspecies re-evolved blue plumage from a black ancestor through genetic changes in ASIP and SCUBE2.

bioRxiv · Sep 3, 2023Evolutionary Biology

Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2

H.-Y. Huang, H.-Y. Liao, X. Chen, S.-W. Wang, C.-W. Cheng, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, Y.-M. Wu, H.-H. Ma, Y.-H. Chang, H.-Y. Tsai, Y.-C. Chou, Y.-P. Hsueh, , C.-H. Wong

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

bioRxiv · May 25, 2021 · PreprintMicrobiology

Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model

C.-Y. Tsai, Y.-C. Chou, C.-Y. Chen, J.-T. Jan, M.-L. Chang, L.-A. Lu, P.-Y. Huang, M. F.- C. Chu, T.-T. Hsu, Y.-P. Hsueh

This study creates a human ACE2 transgenic mouse model to investigate sex-biased SARS-CoV-2 infection and brain cell susceptibility, finding higher mortality in males and altered neuronal responses to the virus.

bioRxiv · May 4, 2021 · PreprintMicrobiology

A CRISPR Screen Identifies Myc-associated Zinc Finger Protein (MAZ) as an Insulator Functioning at CTCF boundaries in Hox Clusters

H. Ortabozkoyun Kara, P.-Y. Huang, H. Cho, V. Narendra, G. LeRoy, J. A. Skok, A. Tsirigos, E. O. Mazzoni, D. Reinberg

The paper identifies MAZ as an insulator functioning at CTCF boundaries in Hox clusters, contributing to genomic architecture during differentiation.

bioRxiv · Aug 25, 2020Biochemistry

NINJA-Associated ERF19 Negatively Regulates Arabidopsis Pattern-Triggered Immunity

P.-Y. Huang, J. Zhang, B. Jiang, J.-H. Yu, Y.-P. Lu, K. Chung, L. Zimmerli

This study identifies ERF19 as a negative regulator of PTI in Arabidopsis, showing that NINJA represses ERF19 to fine-tune immune responses against pathogens.

bioRxiv · Aug 23, 2017Plant Biology