Author

J. A. Van Winkle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:development & morphogenesis· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

T. J. Nice· 4 shared D. A. Constant· 3 shared L. Li· 2 shared A. M. Peters· 1 shared A. P. Wright· 1 shared B. A. Robinson· 1 shared B. T. McCune· 1 shared C. Desai· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersImmunology

T. J. Nice

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4 papers

Recent·Most cited

Transcriptional and Cytotoxic Responses of Human Intestinal Organoids to Interferon Types I, II, and III

D. A. Constant, J. A. Van Winkle, E. VanderHoek, S. E. Dekker, M. A. Sofia, E. Regner, V. L. Tsikitis, N. Modiano, T. J. Nice

This study examines how human intestinal organoids respond to interferon types I, II, and III, revealing differences in transcriptional responses and cytotoxic effects.

bioRxiv · Dec 11, 2021 · PreprintImmunology

A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

J. A. Van Winkle, S. T. Peterson, E. A. Kennedy, M. J. Wheadon, H. Ingle, C. Desai, R. Rodgers, D. A. Constant, A. P. Wright, L. Li, M. Artyomov, S. Lee, M. T. Baldridge, T. J. Nice

The paper shows bacterial microbiota induce localized IFN-lambda-driven antiviral defenses in intestinal epithelial cells, enhancing host resistance to enteric viruses.

bioRxiv · Jun 2, 2021Immunology

Selective interferon responses of intestinal epithelial cells minimize TNFα cytotoxicity

J. A. Van Winkle, D. A. Constant, L. Li, T. J. Nice

This study shows that intestinal epithelial cells preferentially respond to type III IFN, leading to antiviral protection while minimizing TNFα-induced toxicity.

bioRxiv · Mar 20, 2020Immunology

Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells

B. A. Robinson, J. A. Van Winkle, B. T. McCune, A. M. Peters, T. J. Nice

This study shows that cleavage of NS1/2 by caspases in MNV-infected intestinal epithelial cells promotes apoptosis and is required for persistent infection, but not for acute infection in other cell types.

bioRxiv · Mar 26, 2019Microbiology