Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit Cryptosporidium parvum growth
L. Funkhouser-Jones, R. Xu, G. Wilke, Y. Fu, L. A. Shriefer, H. Makimaa, R. Rodgers, E. A. Kennedy, K. VanDussen, T. Stappenbeck, M. T. Baldridge, L. D. Sibley
The paper identifies indole metabolites from the microbiota that inhibit Cryptosporidium parvum growth by disrupting host mitochondrial function and parasite mitosome membrane potential.
bioRxiv · May 25, 2023 · PreprintMicrobiology