Human TLR4 and noncanonical inflammasome differ in their ability to respond to distinct lipid A variants
J. Alexander-Floyd, A. R. Bass, E. M. Harberts, D. Grubaugh, J. D. Buxbaum, I. E. Brodsky, R. K. Ernst, S. Shin
The paper compares how human TLR4 and noncanonical inflammasome sensors CASP4/5 respond to different lipid A structures, finding that acylation state differentially affects their activation.
bioRxiv · Dec 16, 2021 · PreprintImmunology