Author

J. C. Andrechak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. H. Hayes· 3 shared D. E. Discher· 2 shared H. Zhu· 2 shared L. J. Dooling· 2 shared A. H. Chang· 1 shared C. M. Alvey· 1 shared D. Discher· 1 shared J. Irianto· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

B. H. Hayes

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3 papers

Recent·Most cited

Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

B. H. Hayes, M. Wang, H. Zhu, S. H. Phan, J. C. Andrechak, A. H. Chang, L. J. Dooling, M. P. Tobin, T. Marchena, D. Discher

This study shows that chromosomal instability in cancer cells can enhance macrophage-mediated immune responses and induce a broad anti-tumor IgG response, improving survival when combined with CD47-SIRP checkpoint disruption.

bioRxiv · Apr 2, 2023 · PreprintCancer Biology

Titrating CD47 by mismatch CRISPRi reveals incomplete repression can eliminate IgG-opsonized tumors but CD47 heterogeneity limits induction of anti-tumor IgG

B. H. Hayes, H. Zhu, J. C. Andrechak, D. E. Discher

This study uses CRISPRi to titrate CD47 in melanoma cells, showing that incomplete repression can eliminate opsonized tumors but CD47 heterogeneity limits anti-tumor IgG induction.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

J. C. Andrechak, L. J. Dooling, B. H. Hayes, S. Kadu, W. Zhang, R. Pan, M. Vashisth, J. Irianto, C. M. Alvey, D. E. Discher

This study shows engineered macrophages using cooperative phagocytosis eliminate solid tumours and induce anti-tumour IgG, improving immunotherapy outcomes.

bioRxiv · Jan 1, 2022Bioengineering