I. Mogno

Gut microbiota bacterial strain richness is species specific and limits therapeutic engraftment

The paper determines strain richness of common gut species and finds it is species-specific and limited in the gut, with temporary increases from therapeutic administration.

Species-specific CD4+ T cells Enable Prediction of Mucosal Immune Phenotypes from Microbiota Composition

The paper identifies bacterial strains that drive specific mucosal T cell phenotypes using gnotobiotic mice and ex vivo assays, showing strain-specific T cell responses.

Defining Innate Immune Responses to the Human Gut Microbiota from Phylum to Strain

This study screens 277 gut bacterial strains to define innate immune responses, showing strain-specific and phylum-level variations in immune activation.

Strain population structure varies widely across bacterial species and predicts strain colonization in unrelated individuals

The study quantifies strain population sizes across bacterial species and finds prevalent strains in common gut microbiota are more likely to be shared among unrelated individuals.

Quantification of discrete gut bacterial strains following fecal transplantation for recurrent Clostridioides difficile infection demonstrates long-term stable engraftment in non-relapsing recipients

The paper quantifies bacterial strain engraftment after FMT for rCDI and shows long-term stability in non-relapsing recipients, linking strain presence to clinical outcomes.

Strain-level differences in gut microbiome composition determine fecal IgA levels and are modifiable by gut microbiota manipulation

The paper identifies Bacteroides ovatus strains that induce IgA production and shows that manipulating these strains can modify gut IgA levels in mice.

Gut microbiota density influences host physiology and is shaped by host and microbial factors

The paper examines factors influencing gut microbiota density across mammals, disease states, and interventions, finding host and microbial factors shape density and impact health.

Microbial Engraftment and Efficacy of Fecal Microbiota Transplant for Clostridium difficile Patients With and Without IBD

This study evaluates FMT efficacy in CDI patients with and without IBD, finding no difference in recurrence rates and showing engraftment depends on IBD treatment, not disease severity.