Author

J. C. Orr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:organoid / primary culture· 1 Organism:rat· 1

Frequent Co-Authors

R. E. Hynds· 3 shared S. M. Janes· 3 shared C. M. Smith· 2 shared E. F. Maughan· 2 shared K. A. Lazarus· 2 shared M. N. J. Woodall· 2 shared P. De Coppi· 2 shared A. F. Pellegata· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

R. E. Hynds

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A lentiviral toolkit to monitor airway epithelial cell differentiation using bioluminescence

J. C. Orr, A. Laali, P. F. Durrenberger, K. A. Lazarus, M.-B. El Mdawar, S. M. Janes, R. E. Hynds

This paper develops lentiviral reporter constructs to quantitatively monitor airway epithelial cell differentiation using bioluminescence in vitro.

bioRxiv · Feb 9, 2024Cell Biology

Lung viral infection modelling in a bioengineered whole-organ

F. Tommasini, T. Benoist, S. Shibuya, M. N. J. Woodall, E. Naldi, J. C. Orr, G. G. Giobbe, E. F. Maughan, R. E. Hynds, A. Gjinovci, J. C. Hutchinson, O. J. Arthurs, S. M. Janes, N. Elvassore, C. M. Smith, , P. De Coppi

This paper develops a bioreactor-based whole-organ lung model to study viral infections and demonstrates its use for testing antiviral drugs like Remdesivir.

bioRxiv · Feb 1, 2023Bioengineering

Cell-intrinsic differences between human airway epithelial cells from children and adults

E. F. Maughan, R. E. Hynds, A. Pennycuick, E. Nigro, K. H. C. Gowers, C. Denais, S. Gomez-Lopez, K. A. Lazarus, J. C. Orr, D. R. Pearce, S. E. Clarke, D. D. H. Lee, M. N. J. Woodall, T. Masonou, K.-M. Case, , S. M. Janes

The paper compares airway epithelial cells from children and adults, finding intrinsic differences in transcriptional profiles and regenerative capacity.

bioRxiv · Apr 20, 2020Cell Biology