J. C. Reed

Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy

The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.

ATM phosphorylates PP2A subunit A resulting in nuclearexport and spatiotemporal regulation of the DNA damageresponse

This study shows ATM phosphorylates PR65 at S401, regulating DDR by controlling PR65 nuclear-cytoplasmic shuttling and affecting DSB repair and cell survival.

A Pan-respiratory Antiviral Chemotype Targeting a Host Multiprotein Complex

The paper identifies a novel antiviral chemotype effective against multiple respiratory viruses by targeting a host multi-protein complex involved in viral lifecycle and innate immunity.

Identification of an antiretroviral small molecule that appears to be a host-targeting inhibitor of HIV-1 assembly

This paper identifies two small molecules that inhibit HIV-1 assembly by targeting host factors involved in Gag assembly, showing efficacy against drug-resistant strains and lacking resistance mutations in Gag.

The ABCE1 capsid assembly pathway is conserved between primate lentiviruses and the non-primate lentivirus feline immunodeficiency virus

This study shows that feline immunodeficiency virus (FIV) Gag forms assembly intermediates similar to HIV-1, involving ABCE1 and DDX6, indicating conserved viral-host interactions in lentivirus capsid assembly.

HIV-1 initiates genomic RNA packaging in a unique subset of host RNA granules

This paper identifies the packaging initiation complex of HIV-1 genomic RNA as a co-opted host RNA granule and defines the two-step mechanism by which Gag enters this granule to initiate RNA packaging.