Author

R. K. Hite

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Assay:structural biology· 4 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Khan· 2 shared K. Birsoy· 2 shared N. Paknejad· 2 shared T. C. Kenny· 2 shared Y. Son· 2 shared A. Vanden Broeck· 1 shared B. Wang· 1 shared C. Sawyers· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

A. Khan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

Y. Son, T. C. Kenny, A. Khan, K. Birsoy, R. K. Hite

This study identifies FLVCR1 as a transporter for choline and ethanolamine, revealing structural insights into its dual role in the Kennedy pathway.

bioRxiv · Sep 28, 2023Cell Biology

Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor

N. Paknejad, V. Sapuru, R. K. Hite

The paper uses structural analysis to show how Ca2+ binding influences the conformational states of IP3R, explaining its biphasic Ca2+ dependence.

bioRxiv · Dec 29, 2022 · PreprintBiophysics

Integrative genetic analysis identifies FLVCR1 as an essential component of choline transport in mammals

T. C. Kenny, A. Khan, Y. Son, L. Yue, S. Heissel, E. R. Gamazon, H. Alwaseem, R. K. Hite, K. Birsoy

The paper identifies FLVCR1 as essential for choline transport in mammals through integrative genetic analysis and functional studies.

bioRxiv · Oct 5, 2022Cell Biology

Allosteric interactions prime androgen receptor dimerization and activation

E. Wasmuth, A. Vanden Broeck, J. R. LaClair, E. A. Hoover, K. E. Lawrence, N. Paknejad, K. J. Pappas, D. Matthies, B. Wang, W. Feng, P. A. Watson, J. C. Zinder, W. Karthaus, M. J. de la Cruz, R. K. Hite, , C. Sawyers

This study identifies allosteric interactions that prime androgen receptor dimerization and activation, revealing structural and functional mechanisms relevant to development and disease.

bioRxiv · Feb 20, 2022Biochemistry

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175

S. Oh, F. Marinelli, W. Zhou, J. Lee, H. J. Choi, M. Kim, J. D. Faraldo-Gomez, R. K. Hite

The paper investigates the ion selectivity mechanism of TMEM175, showing that its unique hydrophobic constriction and electrostatic field enable K+ selectivity without a canonical filter.

bioRxiv · Nov 5, 2021Biophysics

Mechanisms of loading and release of the 9-1-1 checkpoint clamp

J. C. Castaneda, M. Schrecker, D. Remus, R. K. Hite

The paper presents structures of the yeast checkpoint clamp loader, Rad24-RFC, in complex with 9-1-1 and a 5' junction, revealing mechanisms of 9-1-1 recruitment and release.

bioRxiv · Sep 13, 2021Biophysics