Author

H. J. Choi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:imaging· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Wang· 2 shared J. Lee· 2 shared K. Lee· 2 shared S.-J. Kim· 2 shared A. Desai· 1 shared B. Zhao· 1 shared B.-C. Oh· 1 shared C. Choi· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBioengineering

C. Wang

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Author profile →

5 papers

Recent·Most cited

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175

S. Oh, F. Marinelli, W. Zhou, J. Lee, H. J. Choi, M. Kim, J. D. Faraldo-Gomez, R. K. Hite

The paper investigates the ion selectivity mechanism of TMEM175, showing that its unique hydrophobic constriction and electrostatic field enable K+ selectivity without a canonical filter.

bioRxiv · Nov 5, 2021Biophysics

High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

O.-H. Kim, C. J. Booth, H. S. Choi, J. Lee, J. Kang, J. Hur, H. J. Choi, H. Kim, J.-H. Auh, J.-Y. Cha, Y. J. Lee, C. S. Lee, C. Choi, J.-y. Yang, S.-S. Im, , B.-C. Oh

This study shows that a high-phytate/low-calcium diet causes crystal nephropathies, renal phosphate wasting, and bone loss in rats through tubular dysfunction and altered mineral absorption.

bioRxiv · Oct 29, 2019Physiology

Mechanistic insights into the deleterious role of nasu-hakola disease associated TREM2 variants

R. Dash, H. J. Choi, I. S. Moon

This study investigates how three NHD-associated TREM2 mutations affect protein structure and function through molecular dynamics simulations, revealing structural changes and loss of ligand binding.

bioRxiv · Jul 17, 2019Biochemistry

Deep transfer learning-based hologram classification for molecular diagnostics

S.-J. Kim, C. Wang, B. Zhao, H. Im, J. Min, H. J. Choi, J. Tadros, N. R. Choi, C. M. Castro, R. Weissleder, H. Lee, K. Lee

This paper develops a deep transfer learning method to classify LDIH holograms without image reconstruction, enabling low-cost point-of-care diagnostics.

bioRxiv · Oct 12, 2018Bioengineering

Deconvolution Of Subcellular Protrusion Heterogeneity And The Underlying Actin Regulator Dynamics From Live Cell Imaging

C. Wang, H. J. Choi, S.-J. Kim, A. Desai, N. Lee, D. Kim, Y. Bae, K. Lee

This paper introduces HACKS, a machine learning framework to analyze live cell imaging data and uncover subcellular protrusion heterogeneity and actin regulator dynamics.

bioRxiv · Jan 25, 2018Cell Biology