Author

J. D. Wuerth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Frost· 1 shared A. vom Hemdt· 1 shared B. M. Kuemmerer· 1 shared D. J. Lapp· 1 shared E. Latz· 1 shared F. I. Schmidt· 1 shared F. N. Gohr· 1 shared H. L. Ploegh· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. Frost

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2 papers

Recent·Most cited

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

L.-M. Jenster, K.-E. Lange, S. Normann, A. vom Hemdt, J. D. Wuerth, L. D. J. Schiffelers, Y. M. Tesfamariam, F. N. Gohr, L. Klein, I. H. Kaltheuner, D. J. Lapp, J. Mayer, J. Moecking, H. L. Ploegh, E. Latz, , F. I. Schmidt

This study identifies p38 kinases as a central signaling hub for NLRP1 inflammasome activation in response to ribotoxic stress and virus infection.

bioRxiv · Jan 24, 2022Immunology

Viral Evasion of the Integrated Stress Response Through Antagonistic eIF2-P Mimicry

M. Schoof, L. Wang, J. Z. Cogan, R. Lawrence, M. Boone, J. D. Wuerth, A. Frost, P. Walter

This study shows that SFSV NSs protein evades the ISR by competing with eIF2-P for binding to eIF2B, preserving its activity and allowing viral protein synthesis.

bioRxiv · Jun 7, 2021Biochemistry