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Primary ORCID profile (0000-0001-7060-5097 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints
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9 papers
Recent·Most cited
D. VanInsberghe, D. S. McBride, J. DaSilva, T. J. Stark, M. S. Y. Lau, S. S. Shepard, J. R. Barnes, A. Bowman, A. C. Lowen, K. Koelle
This study examines within-host influenza A virus diversity and evolution in swine, finding low genetic diversity and evidence of purifying selection and genetic drift.
bioRxiv · Oct 23, 2023Evolutionary Biology
Z. Wang, P. Zhou, F. Muecksch, A. Cho, T. B. Tanfous, M. Canis, L. Witte, B. Johnson, R. Raspe, F. Schmidt, E. Bednarski, J. DaSilva, V. Ramos, S. Zong, M. Turroja, , M. C. Nussenzweig
This study compares memory B cell responses after Delta and Omicron BA.1 breakthrough infections versus mRNA vaccine doses, finding that Delta infection boosts overall memory B cell potency and breadth, while Omicron infection only enhances strain-specific responses.
bioRxiv · Aug 11, 2022Immunology
Z. Wang, F. Muecksch, F. Muenn, A. Cho, S. Zong, R. Raspe, V. Ramos, B. Johnson, T. B. Tanfous, J. DaSilva, E. Bednarski, C. Guzman-Cardozo, P. Tober-Lau, D. Hillus, K. Yao, , C. Gaebler
This study compares humoral immune responses to different SARS-CoV-2 vaccination regimens, finding differences in antibody and memory B cell responses and neutralizing breadth against variants.
bioRxiv · May 13, 2022Immunology
A. Cho, F. Muecksch, Z. Wang, T. Ben Tanfous, J. DaSilva, R. Raspe, B. Johnson, E. Bednarski, V. Ramos, D. Schaefer-Babajew, I. Shimeliovich, J. Dizon, K.-H. Yao, F. Schmidt, K. G. Millard, , M. C. Nussenzweig
This study compares memory B cell responses after single-dose Ad26.COV2.S and mRNA vaccines, finding lower quantities but comparable neutralizing quality in Ad26.COV2.S recipients.
bioRxiv · Mar 31, 2022Immunology
F. Muecksch, Z. Wang, A. Cho, C. Gaebler, T. Ben Tanfous, J. DaSilva, E. Bednarski, V. Ramos, S. Zong, B. Johnson, R. Raspe, D. Schaefer-Babajew, I. Shimeliovich, M. Daga, K.-H. Yao, , M. Nussenzweig
This study shows that a third mRNA vaccine dose increases the potency and breadth of SARS-CoV-2 neutralizing antibodies, particularly against the Omicron variant, through the expansion and evolution of memory B cells.
bioRxiv · Feb 14, 2022 · PreprintImmunology
Z. Wang, F. Muecksch, A. Cho, C. Gaebler, H.-H. Hoffmann, V. Ramos, S. Zong, M. Cipolla, B. Johnson, F. Schmidt, J. DaSilva, E. Bednarski, T. B. Tanfous, R. Raspe, K. Yao, , M. C. Nussenzweig
The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.
bioRxiv · Feb 1, 2022 · PreprintImmunology
A. Cho, F. Muecksch, D. Schaefer-Babajew, Z. Wang, S. Finkin, C. Gaebler, V. Ramos, M. Cipolla, P. Mendoza, M. Agudelo, E. Bednarski, J. DaSilva, I. Shimeliovich, J. Dizon, M. Daga, , M. C. Nussenzweig
This study examines memory B cell evolution 5 months after mRNA vaccination in naive individuals, finding increased neutralizing activity but no further breadth or potency, and higher overall plasma neutralizing potency compared to natural infection.
bioRxiv · Jul 29, 2021Immunology
K. Ganti, A. Bagga, J. DaSilva, S. S. Shepard, J. R. Barnes, S. A. Shriner, K. Koelle, A. C. Lowen
This study compares avian influenza A virus reassortment in mallards and guinea pigs, finding higher reassortant frequencies and diversity in mallards.
bioRxiv · Feb 8, 2021Microbiology
Y. Weisblum, F. Schmidt, F. Zhang, J. DaSilva, D. Poston, J. C. C. Lorenzi, F. Muecksch, M. Rutkowska, H.-H. Hoffmann, E. Michailidis, C. Gaebler, M. Agudelo, A. Cho, Z. Wang, A. Gazumyan, , P. D. Bieniasz
The paper shows SARS-CoV-2 variants resistant to neutralizing antibodies can be selected and are present in circulating populations, suggesting the need for combination antibody therapies.
bioRxiv · Jul 21, 2020Microbiology