J. E. Cohen

Nanomechanics of wild-type and mutant dimers of the tip-link protein protocadherin 15

This study examines the nanomechanics of wild-type and V507D mutant PCDH15 dimers, showing that Ca2+ affects their stiffness and unfolding behavior, with implications for hearing.

Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes

This study uses cfChIP-seq on plasma samples to subtype SCLC based on epigenetic states, linking plasma nucleosome data to tumor transcriptomes and developing a classifier for lineage-defining transcription factors.

Multiplexed Single-Molecule Epigenetic Analysis of Plasma-Isolated Nucleosomes for Cancer Diagnostics

The paper develops EPINUC, a single-molecule assay for analyzing plasma nucleosomes to detect cancer with high accuracy, including early-stage colorectal cancer and determining tumor origin.

Alternative splicing of SLAMF6 in human T cells creates a co-stimulatory isoform that counteracts the inhibitory effect of the full-length receptor

This study identifies an alternative splicing event in SLAMF6 that generates a co-stimulatory isoform, which enhances T cell cytotoxicity and is associated with improved anti-tumor responses in melanoma.

SLAMF6 deficiency augments tumor killing and skews towards an effector phenotype revealing it as a new T cell checkpoint

This study shows that SLAMF6 deficiency enhances T cell tumor-killing ability and shifts T cells toward an effector phenotype, suggesting SLAMF6 as a new immune checkpoint.