J. G. Valenzuela

This study shows that centrin-deficient L. mexicana parasites protect against Old World visceral leishmaniasis in a hamster model by reducing parasite burden and altering cytokine responses.

This study shows IgM antibodies facilitate Leishmania genetic hybridization in vitro and in vivo, leading to full genome hybrids and increased genetic exchange.

This study evaluates immune responses to mosquito bites in humans, identifying key genes, cell types, and pathways involved in innate and adaptive immunity.

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.

This study uses RNA-Seq to analyze midgut gene expression changes in sand flies infected with Leishmania, finding limited differential expression with stage-specific effects.

The paper identifies stage-specific gene expression markers in Leishmania infantum during its development in the sand fly vector using RNAseq and differential expression analysis.