Author

D. R. Schmidt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. G. Vander Heiden· 4 shared B. T. Do· 2 shared I. M. T. Gramatikov· 2 shared K. L. Abbott· 2 shared P. P. Hsu· 2 shared R. Ferreira· 2 shared A. Ali· 1 shared A. C. Liu· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCancer Biology

M. G. Vander Heiden

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4 papers

Recent·Most cited

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

K. L. Abbott, A. Ali, D. Casalena, B. T. Do, R. Ferreira, J. H. Cheah, C. K. Soule, A. Deik, T. Kunchok, D. R. Schmidt, S. Renner, S. E. Honeder, M. Wu, S. H. Chan, T. Tseyang, , M. G. Vander Heiden

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

bioRxiv · Feb 25, 2023Cancer Biology

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

B. T. Do, P. P. Hsu, S. Y. Vermeulen, Z. Wang, T. Hirz, K. L. Abbott, N. Aziz, J. M. Replogle, S. Bjelosevic, J. Paolino, S. Nelson, S. Block, A. M. Darnell, R. Ferreira, H. Zhang, , M. G. Vander Heiden

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

bioRxiv · Aug 16, 2022Cancer Biology

Ablative radiotherapy improves survival in autochthonous cancer mouse models

D. R. Schmidt, I. M. T. Gramatikov, A. Sheen, C. L. Williams, M. Hurwitz, L. E. Dodge, E. Holupka, W. S. Kiger, M. R. Cornwall-Brady, W. Huang, H. H. Mak, K. Cormier, C. Condon, D. Wittrup, O. H. Yilmaz, , M. G. Vander Heiden

This study shows that ablative radiotherapy improves survival in autochthonous cancer mouse models and synergizes with androgen deprivation in prostate cancer.

bioRxiv · Jul 1, 2022 · PreprintCancer Biology

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

S. M. Davidson, J. E. Heyman, J. P. O'Brien, A. C. Liu, D. R. Schmidt, W. J. Israelsen, T. L. Dayton, R. Sehgal, R. Bronson, E. Freinkman, H. Mak, S. Malstrom, G. Bellinger, A. Carracedo, P. P. Pandolfi, , M. G. Vander Heiden

The paper investigates the role of pyruvate kinase isoforms in prostate cancer, finding that Pkm1 suppresses cancer while Pkm2 promotes it, and that a PKM1-like activator can suppress tumor progression.

bioRxiv · May 9, 2021Cancer Biology