Author

M. B. Loughrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Assay:imaging· 2 Approach:statistical model· 2

Frequent Co-Authors

P. D. Dunne· 3 shared D. B. Longley· 2 shared H. G. Coleman· 2 shared M. Lawler· 2 shared P. Bankhead· 2 shared S. Tejpar· 2 shared A. Corwin· 1 shared A. D. Campbell· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

P. D. Dunne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

E. Gil Vazquez, N. Nasreddin, G. N. Valbuena, E. J. Mulholland, H. L. Belnoue-Davis, H. Eggington, R. O. Schenck, V. M. Wouters, P. Wirapati, K. Gilroy, T. R. M. Lannagan, D. J. Flanagan, A. K. Najumudeen, S. Omwenga, A. M. B. McCorry, , S. J. Leedham

The paper examines stem cell population dynamics in colorectal tumors, showing that CBC-RSC admixture correlates with mutations and microenvironmental changes, and is linked to chemoresistance.

bioRxiv · Jun 11, 2022Cancer Biology

Development of a semi-automated method for tumor budding assessment in colorectal cancer and comparison with manual methods

N. C. Fisher, M. B. Loughrey, H. G. Coleman, M. D. Gelbard, P. Bankhead, P. D. Dunne

This study develops a semi-automated method for tumor budding assessment in colorectal cancer and compares it with manual methods, finding strong correlation and higher detection rates with the new approach.

bioRxiv · Jun 17, 2021Pathology

Stratification Of Chemotherapy-Treated Stage III Colorectal Cancer Patients Using Multiplexed Imaging And Single Cell Analysis Of T Cell Populations

X. Stachtea, M. B. Loughrey, M. Salvucci, A. Lindner, S. Cho, E. McDonough, A. Sood, J. Graf, A. Santamaria-Pang, A. Corwin, P. Laurent-Puig, S. Dasgupta, S. Van Schaeybroeck, M. Lawler, J. H. M. Prehn, , D. B. Longley

This study uses multiplexed imaging and single-cell analysis to classify immune cells in stage III colorectal cancer patients, finding that multi-marker Treg classification better predicts survival than single markers.

bioRxiv · Feb 24, 2021Cancer Biology

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

P. D. Dunne, H. G. Coleman, P. Bankhead, M. Alderdice, R. T. Gray, S. McQuaid, V. Bingham, M. B. Loughrey, J. A. James, A. M. McCorry, A. Gilmore, C. Holohan, D. Klingbiel, S. Tejpar, P. G. Johnston, , M. Lawler

The paper identifies Bcl-xL as a prognostic biomarker and predictor of response to adjuvant chemotherapy in BRAF-mutant stage II/III colon cancer using gene expression and immunohistochemistry validation.

bioRxiv · Oct 23, 2017Cancer Biology