Author

P. Cheung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 2 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Organism:mouse· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2

Frequent Co-Authors

J. Wang· 2 shared X. Huang· 2 shared A. Beck· 1 shared A. Csoti· 1 shared A. Ganesan· 1 shared A. Habtezion· 1 shared A. Kuo· 1 shared A. Muller· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersCancer Biology

J. Wang

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

J. D. Lee, B. L. Menasche, M. Mavrikaki, M. M. Uyemura, S. M. Hong, N. Kozlova, J. Wei, M. M. Alfajaro, R. Filler, A. Muller, T. Saxena, R. R. Posey, P. Cheung, T. Muranen, J. Heng, , F. J. Slack

This study shows that SARS-CoV-2 variants differ in syncytia formation, which affects host chromatin accessibility, cellular senescence, and inflammation via TP53.

bioRxiv · Aug 31, 2023Microbiology

BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune CheckpointSensitivity in BRAFV600E-mutant Glioma

Y. L. Xing, D. Panovska, J.-W. Park, S. Grossauer, K. Koeck, B. Bui, E. Nasajpour, J. J. Nirschl, Z.-P. Feng, P. Cheung, P. Habib, R. Wei, J. Wang, W. Thomason, J. Xiu, , C. K. Petritsch

This study shows that BRAF/MEK inhibition induces cell state transitions in BRAFV600E-mutant gliomas, leading to PD-L1 upregulation and immune evasion, which can be overcome by combining with immune checkpoint inhibition.

bioRxiv · Feb 3, 2023Cancer Biology

Crosstalk of Histone Modifications in the Healthy Human Immune System

D. Dermadi, L. Kalesinskas, A. Ganesan, A. Kuo, P. Cheung, S. Cheng, M. Dvorak, T. Scriba, A. Habtezion, M. Donato, P. J. Utz, P. Khatri

The paper analyzes histone post-translational modifications in human immune cells to uncover their interactions and functional implications.

bioRxiv · Jan 21, 2022 · PreprintImmunology

An Efficient Method to Quantify Structural Distributions in Heterogeneous cryo-EM Datasets

H. Gu, W. Wang, I. C. UNARTA, W. Zeng, F. K. Sheong, P. Cheung, S. Liu, Y. Yao, X. Huang

This paper introduces LCTC, a method to quantify structural distributions in heterogeneous cryo-EM datasets, showing improved performance over existing methods on simulated and experimental data.

bioRxiv · May 27, 2021 · PreprintBiophysics

Stiffness Regulates Intestinal Stem Cell Fate

S. He, L. Peng, W. Kang, P. Cheung, T. Xu, M. Mana, C. Y. Park, H. Wang, S. Imada, J. O. Russell, J. Wang, R. Wang, Z. Zhou, K. Chetal, E. Stas, , N. Saeidi

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

bioRxiv · Mar 15, 2021Cell Biology

EPIGENETIC MODULATION VIA THE C-TERMINAL TAIL OF H2A.Z

L. Imre, P. Nanasi, I. Benhamza, K. N. Enyedi, G. Mocsar, R. Bosire, E. Hegedus, E. F. Niaki, A. Csoti, Z. Darula, E. Csosz, S. Poliska, B. Scholtz, G. Mezo, Z. Bacso, , G. Szabo

The paper shows that the C-terminal tail of H2A.Z affects nucleosome stability and chromatin structure, with targeted peptides altering gene expression and chromatin sensitivity.

bioRxiv · Feb 22, 2021Cell Biology

Role of 1'-Ribose Cyano Substitution for Remdesivir to Effectively Inhibit both Nucleotide Addition and Proofreading in SARS-CoV-2 Viral RNA Replication

L. Zhang, D. Zhang, C. Yuan, X. Wang, Y. Li, X. Jia, X. Gao, H.-L. Yen, P. Cheung, X. Huang

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

bioRxiv · Apr 27, 2020Biophysics

A lncRNA/Lin28/Let7 Axis Coupled To DNA Methylation Fine Tunes The Dynamics Of A Cell State Transition

M. A. Li, P. P. Amaral, P. Cheung, J. H. Bergmann, M. Kinoshita, T. Kalkan, M. Ralser, S. Robson, F. von Meyenn, M. Paramor, F. Yang, C. Chen, J. Nichols, D. L. Spector, T. Kouzarides, , A. Smith

The paper identifies a lncRNA/miRNA/DNA methylation axis that regulates the timing of stem cell state transition from naive pluripotency.

bioRxiv · Apr 26, 2017Cell Biology