Author

M. M. Alfajaro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 7 Approach:experimental assay· 6 Organism:human· 6 Organism:mouse· 4 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. B. Wilen· 7 shared J. Wei· 6 shared R. B. Filler· 4 shared A. Iwasaki· 2 shared B. Israelow· 2 shared B. L. Menasche· 2 shared E. Song· 2 shared J. S. Chen· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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7 shared papersMicrobiology

C. B. Wilen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

J. D. Lee, B. L. Menasche, M. Mavrikaki, M. M. Uyemura, S. M. Hong, N. Kozlova, J. Wei, M. M. Alfajaro, R. Filler, A. Muller, T. Saxena, R. R. Posey, P. Cheung, T. Muranen, J. Heng, , F. J. Slack

This study shows that SARS-CoV-2 variants differ in syncytia formation, which affects host chromatin accessibility, cellular senescence, and inflammation via TP53.

bioRxiv · Aug 31, 2023Microbiology

Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses

M. S. Strine, W. L. Cai, J. Wei, M. M. Alfajaro, R. B. Filler, S. B. Biering, S. Sarnik, A. Patil, K. S. Cervantes, C. K. Collings, P. C. DeWeirdt, R. E. Hanna, K. Schofield, C. Hulme, S. Konermann, , C. B. Wilen

This study shows DYRK1A promotes viral entry of SARS-CoV, SARS-CoV-2, and MERS-CoV by regulating ACE2 and DPP4 transcription without its kinase activity.

bioRxiv · Sep 13, 2022 · PreprintMicrobiology

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells

J. S. Chen, R. D. Chow, E. Song, T. Mao, B. Israelow, K. Kamath, J. Bozekowski, W. A. Haynes, R. B. Filler, B. L. Menasche, J. Wei, M. M. Alfajaro, W. Song, L. Peng, L. Carter, , S. C. Eisenbarth

The paper shows that high-affinity, neutralizing antibodies against SARS-CoV-2 can be produced without T follicular helper cells through alternative pathways.

bioRxiv · Jun 10, 2021Immunology

Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection

R. A. Flynn, J. A. Belk, Y. Qi, Y. Yasumoto, C. O. Schmitz, M. R. Mumbach, A. Limaye, J. Wei, M. M. Alfajaro, K. R. Parker, H. Y. Chang, T. L. Horvath, J. E. Carette, C. Bertozzi, C. B. Wilen, A. T. Satpathy

This study identifies 309 host proteins interacting with SARS-CoV-2 RNA during infection and reveals their roles in virus-induced cell death and mitochondrial dysfunction.

bioRxiv · Oct 6, 2020 · PreprintMicrobiology

Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication

J. S. Chen, M. M. Alfajaro, J. Wei, R. D. Chow, R. B. Filler, S. C. Eisenbarth, C. B. Wilen

This study investigates the effect of NSAIDs on SARS-CoV-2 infection and finds that COX-2 is induced by the virus but NSAIDs do not impact viral entry or replication.

bioRxiv · Sep 24, 2020 · PreprintMicrobiology

CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus

V. R. Graziano, M. M. Alfajaro, C. Schmitz, R. B. Filler, M. S. Strine, J. Wei, L. L. Hsieh, M. T. Baldridge, T. J. Nice, S. Lee, R. C. Orchard, C. B. Wilen

This study uses a Cd300lf conditional knockout mouse to show that CD300lf on tuft cells is essential for persistent MNoVCR6 infection, while myelomonocytic cells are major targets for non-persistent MNoVCW3, with STAT1 restricting its tropism.

bioRxiv · Aug 19, 2020Microbiology

Neuroinvasion of SARS-CoV-2 in human and mouse brain

E. Song, C. Zhang, B. Israelow, A. Lu-Culligan, A. Sprado, S. Skriabine, P. Lu, O.-E. Weizman, F. Liu, Y. Dai, K. Szigeti-Buck, Y. Yasumoto, G. Wang, C. Castaldi, J. Heltke, , A. Iwasaki

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

bioRxiv · Jun 25, 2020Microbiology