Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
B. Popovic, B. P. Nicolet, A. Guislain…·M. C. Wolkers
The paper identifies RNA binding proteins regulating cytokine production in T cells over time, showing how they influence effector function and anti-tumor responses.
J. J. Freen-van Heeren, B. Popovic, A. Guislain, M. C. Wolkers
This study shows that AU-rich elements in the IFNG 3UTR regulate IFN-γ production in human T cells, with ARE deletion increasing sustained cytokine production and anti-tumor responses.
R. de Groot, M. M. van Loenen, A. Guislain…·M. C. Wolkers
The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.
F. Salerno, J. J. Freen-van Heeren, A. Guislain…·M. Wolkers
This study shows TLR2 ligands lower antigen thresholds for cytokine production and enhance polyfunctional CD8+ T cell responses through mRNA stabilization and costimulation.
F. Salerno, A. Guislain, J. J. Freen-van Heeren…·M. C. Wolkers
The paper shows that post-transcriptional regulation, specifically mRNA stability, limits IFN-γ production in tumor-infiltrating T cells, and restoring this stability enhances anti-tumor effects.