M. C. Wolkers

This study shows that tumor-infiltrating lymphocytes (TILs) can be effectively generated from metastatic NSCLC lesions regardless of location or prior treatments, with 76% showing anti-tumoral activity.

The paper identifies RNA binding proteins regulating cytokine production in T cells over time, showing how they influence effector function and anti-tumor responses.

The paper maps RNA-binding protein (RBP) expression in human B and T cells during differentiation, revealing cell-type-specific and differentiation-dependent patterns.

The paper identifies CD29 as a marker to enrich for cytotoxic human CD4+ T cells, showing they express cytotoxic genes and kill target cells.

The paper examines TILs from RCC patients, finding that while some are tumor-reactive, they fail to produce key cytokines in response to autologous tumors.

The study finds that mRNA expression poorly predicts protein levels in CD8+ T cells, but gene class and characteristics like sequence conservation and UTR length influence this relationship.

This study shows that AU-rich elements in the IFNG 3UTR regulate IFN-γ production in human T cells, with ARE deletion increasing sustained cytokine production and anti-tumor responses.

The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.

The paper shows that post-transcriptional regulation, specifically mRNA stability, limits IFN-γ production in tumor-infiltrating T cells, and restoring this stability enhances anti-tumor effects.

The paper analyzes circRNA expression in human hematopoietic cells, finding cell-type specific patterns and increased expression during maturation.