A. Guislain

Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products

This study identifies that high B cell infiltrates in NSCLC tumors, associated with tertiary lymphoid structures, negatively correlate with the tumor-reactivity of expanded TIL products.

Regulation of IFNgamma production by ZFP36L2 in T cells is context-dependent

This study shows ZFP36L2 regulates IFNγ production in T cells differently depending on activation context and time, by destabilizing Ifng mRNA in an AU-rich element-dependent manner.

Learning the sequence code of protein expression in human immune cells

SONAR, a machine learning pipeline, learns the sequence code for protein abundance in human immune cells, revealing cell type-specific and activation-dependent sequence features that can enhance T cell receptor expression.

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.

Effective generation of tumor-infiltrating lymphocyte products from metastatic non-small-cell lung cancer (NSCLC) lesions irrespective of location and previous treatments.

This study shows that tumor-infiltrating lymphocytes (TILs) can be effectively generated from metastatic NSCLC lesions regardless of location or prior treatments, with 76% showing anti-tumoral activity.

Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function

The paper identifies RNA binding proteins regulating cytokine production in T cells over time, showing how they influence effector function and anti-tumor responses.

CD29 enriches for cytotoxic human CD4+ T cells

The paper identifies CD29 as a marker to enrich for cytotoxic human CD4+ T cells, showing they express cytotoxic genes and kill target cells.

Human T cells employ conserved AU-rich elements to fine-tune IFN-γ production

This study shows that AU-rich elements in the IFNG 3UTR regulate IFN-γ production in human T cells, with ARE deletion increasing sustained cytokine production and anti-tumor responses.

CD29 marks superior cytotoxic human CD8+ T cells

This study identifies CD29 as a marker for cytotoxic CD8+ T cells, showing its stability and utility in enhancing anti-tumoral activity.

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.

Costimulation through TLR2 drives polyfunctional CD8+ T cell responses

This study shows TLR2 ligands lower antigen thresholds for cytokine production and enhance polyfunctional CD8+ T cell responses through mRNA stabilization and costimulation.

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

The paper shows that post-transcriptional regulation, specifically mRNA stability, limits IFN-γ production in tumor-infiltrating T cells, and restoring this stability enhances anti-tumor effects.